In females, the mid-cycle surge in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion triggers ovulation. This neuroendocrine process is mediated by a population of neurons in the preoptic area that produce the neuropeptide kisspeptin and drive the activity of GnRH neurons for the surge. In female rodents, and possibly in other species, the preovulatory surge is timed to precede the onset of activity to ensure that ovulation coincides with sexual behavior. In this presentation, I will focus on the regulation of preoptic area kisspeptin neuron activity by the central circadian clock.
System: Human
Mechanisms regulating GnRH neurons
The brain, it makes hormones with zeal.
The control of our gonads is real.
The cells they call candy,
Are certainly dandy.
But what about non-neural glia?
The impacts of IVF and other Assisted Reproductive Technologies (ART) on human reproduction with Dr Rebecca Krisher
This is the second episode in our series on Breakthroughs in Reproductive Technologies. Here Dr Jane Fenelon and Dr Rachel West talk to Dr Rebecca Krisher about the impact that Assisted Reproductive Technologies (ART) have had on human reproduction. Join us as we learn more about the common procedures that are available to us today and their efficacy and about some of the controversies surrounding ‘add-ons’ on offer in the IVF clinic We also try and answer some of the big questions like when should women start thinking about their fertility? And what does the future hold? As well as a fascinating insight into Rebecca’s career journey so far and tips for trainees.