Experimental Methods and Techniques in Reproduction Webinar: “Spatiotemporal Dynamics of Murine Ovarian Aging”
Dr. Chung will present her recent work, which leverages spatial transcriptomics and advanced computational methods to map ovarian tissue dynamics across the reproductive lifespan in mice. By integrating single-cell, spatial, and histological data, her work reveals how cellular interactions, the temporal coordination of folliculogenesis, and patterns of inflammatory remodeling change with age. These findings, recently reported in Lan et al., bioRxiv 2024, reveal new principles of ovarian homeostasis and provide a framework for understanding the molecular drivers of reproductive aging.
Hattie Chung is an Assistant Professor at Yale School of Medicine in the Department of Medicine with appointments in the Department of Molecular, Cellular and Developmental Biology (MCDB) and the Department of Obstetrics, Gynecology and Reproductive Sciences. She is a systems and computational biologist whose lab develops and applies cutting-edge single-cell and spatial genomic technologies to understand how cellular organization supports tissue function. Her research focuses on the molecular basis of tissue homeostasis in ovarian aging and cardiovascular disease, integrating experimental and computational approaches to uncover new principles of reproductive and vascular biology.