Title: Development of a new non-hormonal contraceptive targeting the AMH/AMHR2 axis in females.
Description: Anti-Müllerian hormone (AMH) is a paracrine factor produced by growing follicles that mediates negative feedback on the activation and growth of new pre-antral follicles. Sustained supraphysiological AMH can suppress follicular development and induce contraception. Herein we will present findings on the mechanism of action of AMH in follicles, the development of new contraceptive modalities including gene therapy with AMH and small molecule agonists of the AMH receptor (AMHR2), and their evaluation in several animal models from mice to cats.
These webinars, sponsored by the Society for the Study of Reproduction (SSR), Frontiers in Reproduction (FIR), and the Bill & Melinda Gates Foundation, will focus on emerging technologies and approaches to male and female contraception.
Speakers:
Dr. Lonny R. Levin, Professor of Pharmacology, Weill Cornell Medical College
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Title: On-demand nonhormonal male contraception via ADCY10 inhibition
Description: Fast-acting sAC inhibitors with slow off-rates can provide safe, pre-coital, on-demand contraception for men which is nonhormonal, orally available, easily tolerated, fast-acting, and readily reversible.
Dr. Celia Santi, Associate Professor of OBGYN, Washington University School of Medicine in St. Louis
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Title: Targeting the sperm-specific K+ channel SLO3 for non-hormonal contraception.
Description: Identification of inhibitors of the sperm specific SLO3 K+ channel that can be developed into a non-hormonal class of female contraceptives that act by targeting sperm capacitation.
These webinars, sponsored by the Society for the Study of Reproduction (SSR), Frontiers in Reproduction (FIR), and the Bill & Melinda Gates Foundation, will focus on emerging technologies and approaches to male and female contraception.
Speakers:
Dr. Jianjun Sun, Associate Professor, Department of Physiology & Neurobiology, University of Connecticut, Storrs
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Title: Screening female contraceptive compounds using Drosophila ovulation model
Description: In my presentation, I will introduce the ovulation mechanism in Drosophila and describe the platform utilizing Drosophila ovulation to screen contraceptive compounds that can effectively inhibit follicle rupture.
Dr. Phil Santangelo, Associate Professor of Biomedical Engineering, Georgia Tech University & Emory University
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Title: Intravaginal delivery of mRNA encoded contraceptive antibodies
