Development of a new non-hormonal contraceptive targeting the AMH/AMHR2 axis in females.
Speaker: Dr. David Pépin, Harvard Medical School
Title: Development of a new non-hormonal contraceptive targeting the AMH/AMHR2 axis in females.
Description: Anti-Müllerian hormone (AMH) is a paracrine factor produced by growing follicles that mediates negative feedback on the activation and growth of new pre-antral follicles. Sustained supraphysiological AMH can suppress follicular development and induce contraception. Herein we will present findings on the mechanism of action of AMH in follicles, the development of new contraceptive modalities including gene therapy with AMH and small molecule agonists of the AMH receptor (AMHR2), and their evaluation in several animal models from mice to cats.
Resource Category: Female Reproduction | System: Mammal, Mouse | Topic: Contraception, Hormone | Series: Opening Gates: New Methods and Approaches for Effective Contraception in Both Sexes